Introduction: Sulfur Mustard is an important field of research for Iranian scientists since 1983. This was from time that Iraq army used this chemical weapon against Iranians causing injury over more than 30,000 people still suffering from its late effects. Evidence Acquisition: This study has been collected from studies of searching online databases that have been studied in our review article. Results: Sulfur Mustard is synthesized by different methods, its exposure can cause severe, irreversible damage to skin, respiratory tract and eyes. In the eye, it has a wide spectrum effects. This effect begins with the asymptomatic period following irritation and redness and ends with damage to corneal structure with photophobia, temporary blindness and blepharospasm. Conclusion: Based on this here we are mentioning some of the attempts to better defined aspects .of Sulfur Mustard affects and mechanisms Author: Masoud Reza Gholi Zamenjani